There's a replicable weather glitch where if you're in Las Venturas during a sandstorm at sunset and fly fast enough to San Fierro or Flint County, the horizon gets 'stuck' as a foggy dark red that persists until nightfall. The game fails to properly transition the weather systems between regions in time.
A palm tree in GTA San Andreas is so inconveniently placed that pedestrians spawn on it and immediately fall off.
GTA: San Andreas
This prop in GTA San Andreas makes a sound almost no other decoration can
GTA: San Andreas
Saving at Madd Dogg's mansion permanently breaks every basketball court in the game
GTA: San Andreas
The satellite dish is so tall that planes constantly suicide into it—and your girlfriend will call to complain.
GTA: San Andreas
Ghost planes: the crashing aircraft have NO pilots—for a weirdly practical reason.
GTA: San Andreas
The 'Ghost Car' on Mount Chiliad isn't a ghost at all — it's a glitch that turns bike race paths into highways for random traffic.
GTA: San Andreas